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The Choi Lab

Publications

(* These authors contributed equally to this work)

Gething. C.*, Ferrar, J.*, Misra, B., Howells, G., Choi, U.B. "Conformational Change of Syntaxin-3b in Regulating SNARE Complex Assembly in the Ribbon Synapses." 2021 (under review) Biorxiv (ID: BIORXIV/2021/459295)

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van Dorp, S., Qiu, R., Choi, U.B., Wu, M.M., Yen, M., Kirmiz, M., Brunger, A.T., Lewis, R.S. "Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1." Elife. 2021 Nov 3;10:e66194.

Wilson, S.C., White, K.I., Zhou, Q., Pfuetzner, R.A., Choi, U.B., Sudhof, T.C., Brunger, A.T. “Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing.” EMBO J. 2019 Sep 30:e101603.

Choi, U.B., Sanabria, H., Smirnova, T., Bowen, M.E., Weninger, K.R. “Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins.” Biomolecules. Mar 22;9(3). pii: E114

Brunger, A.T., Choi, U.B., Lai, Y., Leitz, J., White, K.I., Zhou, Q. “The pre-synaptic fusion machinery.” Curr Opin Struct Biol. 2019 Feb:54:179-188

White, K.I.*, Zhao, M.*, Choi, U.B., Pfuetzner, R.A., Brunger, A.T. “NSF-coordinated SNARE disassembly through a conserved pore loop interaction.” Elife. 2018 Sep 10;7 pii: e38888

Choi, U.B.*, Zhao, M.*, White, K.I., Zhou, Q., Pfuetzner, R.A., Brunger, A.T. “Single SNARE complex recycling by NSF.” Elife. 2018 Jul 9;7 pii: e36497

Brunger, A.T., Leitz, J., Zhou, Q., Choi, U.B., Lai, Y. “Ca2+-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition.” Trends Cell Biol. 2018 Aug;28(8):631-645

Brunger, A.T., Choi, U.B., Lai, Y., Leitz, J., Zhou, Q. “Molecular Mechanisms of Fast Neurotransitter Release.” Annu Rev Biophys. 2018 May 20; 47:469-497

Lai, Y.*, Choi, U.B.*, Leitz J., Rhee H.J., Lee C., Altas B., Zhao, M., Pfuetzner, R.A., Wang, A.L., Brose N., Rhee J.S., Brunger, A.T. “Molecular Mechanisms of synaptic vesicle priming by Munc13 and Munc18.” Neuron. 2017 Aug 2; 95(3):591-607.e10.
- Featured in Neuron Perspective and PNAS Journal Club

Wang, S.*, Choi, U.B.*, Gong, J.*, Yang, X., Li, Y., Wang, A.L., Yang, X., Brunger, A.T., Ma, C. “Conformational Change of Syntaxin Linker Region induced by Munc13s Initiates SNARE Complex Formation in Synaptic Exocytosis.” EMBO J. 2017 Jan 30. pii: e201695775

Gong, J., Lai, Y., Li, X., Wang, M., Leitz, J., Hu, Y., Zhang, Y., Choi, U.B., Cipriano, D.J., Pfuetzner, R.A., Sudhof, T.C., Yang, X., Brunger, A.T., Diao, J., “The C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.” Proc Natl Acad Sci. 2016 Nov 22;113(47):E7590-E7599.

Lai, Y., Choi, U.B., Zhang, Y., Zhao, M., Pfuetzner, R.A., Wang, A.L., Diao, J., Brunger, A.T. “N-terminal domain of complexin independently activates calcium-triggered fusion.” Proc Natl Acad Sci. 2016 Aug 9;113(32):e4698-707

Choi, U.B., Zhao, M., Zhang, Y., Lai, Y., Brunger, A.T. “Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.” Elife. 2016 Jun 2;5 pii: e16886

Zhou, Q., Lai, Y., Bacaj, T., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Brewster, A.S., Sauter, N.K., Cohen, A.E., Soltis, S.M., Alonso-Mori, R., Chollet, M., Lemke, HT., Pfuetzner, R.A., Choi, U.B., Weis, W.I., Diao, J., Südhof, T.C., Brunger , A.T. “Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.” Nature. 2015 Sep 3;525(7567):62-7

Zhang, Y., Diao, J., Colbert, K.N., Lai, Y., Pfuetzner, R.A., Padolina, M.S., Vivona, S., Ressl, S., Cipriano, D.J., Choi, U.B., Shah, N., Weis, W.I., Brunger, A.T. “Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.” J Biol Chem. 2015 Apr 17;290(16):10518-34

McCann, J.J.*, Choi, U.B.*, Bowen, M.E. “Reconstitution of multivalent PDZ domain binding to the scaffold protein PSD-95 reveals ternary-complex specificity of combinatorial inhibition.” Structure. 2014 Oct 7;22(10):1458-66.

Choi, U.B., Kazi R., Stenzoski N., Wollmuth L.P., Uversky V.N., Bowen M.E. “Modulating the Intrinsic disorder in the cytoplasmic domain alters the biological activity of the N-methyl-D -aspartate-sensitive glutamate receptor.” J Biol Chem. 2013 Aug 2;288(31):22506-15.

Choi, U.B., Weninger, K., Bowen, M.E. “Immobilization of proteins for single-molecule fluorescence resonance energy transfer measurements of conformation and dynamics.” Methods Mol Biol. 2012;896:3-20

Choi, U.B., Xiao, S., Wollmuth, L.P., Bowen, M.E. “Effect of Src Kinase phosphorylation on disordered C-terminal domain of N-methyl-D-aspartic acid (NMDA) receptor subunit GluN2B protein.” J Biol Chem. 2011 Aug 26;286(34):29904-12.
- Rated Must Read in Faculty of 1000 http://f1000.com/11732960

Choi, U.B., Bowen, M.E., Weninger, K. “Beyond the Random Coil: Stochastic Conformational Switching in Intrinsically Disordered Proteins.” Structure. 2011 Apr 13;19(4):566-76 .
- Selected by the editors as Featured Article

McCann, J.J., Choi, U.B., Zheng, L., Weninger, K., Bowen, M.E. “Optimizing methods to recover absolute FRET efficiency from immobilized single molecules.” Biophys J. 2010 Aug 4;99(3):961-70.

Choi, U. B., Vrljic, M., Strop, P., Chu, S., Brunger, A. T., Weninger, K. “Single molecule FRET derived model of the synaptotagmin 1 – SNARE fusion complex.” Nat Struct Mol Biol. 2010 Mar;17(3):318-24.
- Selected by the editors as Featured Article

Weninger, K., Bowen, M.E., Choi, U.B., Chu, S., Brunger, A.T. “Accessory proteins stabilize the acceptor complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 complex.” Structure 2008 Feb 12; 16(2): 308-320.
- Selected by the editors as Featured Article

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